Directly Energized Uptake of β-Estradiol 17-(β-d-Glucuronide) in Plant Vacuoles Is Strongly Stimulated by Glutathione Conjugates
نویسندگان
چکیده
منابع مشابه
Effects of 17-β estradiol on neurogenesis in the hippocampus of ovariectomized mice
Background & Aims: Adult neurogenesis occurs in the two main areas of the brain of most mammalian species in; sub ventricular zone, and the dentate gyrus of the hippocampus. Many factors such as 17-β estradiol affect neurogenesis in the hippocampus. The aim of this study was to investigate the effect of exogenous 17-β estradiol on neurogenesis in the ovariectomized (OVX) mice. Materials & Meth...
متن کاملA Review on 17-β estradiol a Potent Therapeutic Factor of Diabetic Cardiomyopathy
Type 2 diabetes causes structural and functional changes in the myocardium, which is called cardiomyopathy. Diabetic cardiomyopathy (DCM) is a distinct primary disorder process, independent of coronary artery disease, which leads to heart failure in diabetic patients. Also, DCM is a multifaceted disorder that is one of the leading causes of death in elderly and postmenopausal women. Menopause i...
متن کاملChronic estradiol - 17 β exposure increases superoxide production in the
1 Women are exposed to estrogen in several forms such as oral contraceptive pills and 2 hormone replacement therapy. Although estrogen was believed to be cardioprotective, 3 lately, its beneficial effects are being questioned. Recent studies indicate that oxidative 4 stress in the rostral ventrolateral medulla (RVLM) may play a role in the development of 5 hypertension. Therefore, we hypothesiz...
متن کاملCytochrome P450-mediated Oxidation of Glucuronide Derivatives: Example of Estradiol-17 -glucuronide Oxidation to 2-hydroxy- Estradiol-17 -glucuronide by Cyp 2c8
In the classical metabolic oxidation scheme, hydrophobic endogenous or xenobiotic compounds undergo phase I oxidation, generally catalyzed in the liver by cytochromes P450, followed by phase II conjugation reactions, in a way that allows much more polar metabolites to be expelled from the cell through active transport mechanisms. Cytochrome P450-mediated oxidation of steroid sulfate has been de...
متن کامل17-β estradiol protects ARPE-19 cells from oxidative stress through estrogen receptor-β.
PURPOSE To elucidate the mechanism of 17-β estradiol (17β-E(2))-mediated protection of retinal pigment epithelium (RPE) from oxidative stress. METHODS Cultured ARPE-19 cells were subjected to oxidative stress with t-butyl hydroxide or hydrogen peroxide in the presence or absence of 17β-E(2). Reactive oxygen species (ROS) were measured using H(2)DCFDA fluorescence. Apoptosis was evaluated by c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.1.262